Significant Weight Loss
Losing 50+ pounds with peptide assistance
Who is this for?
- • People with 50+ lbs to lose
- • Those starting at a higher weight
- • Anyone looking for major transformation
674 posts
343 users
What the Community Reports
Aggregated outcomes from community discussions about significant weight loss.
118
Users sharing results
276
Users with stated goals
160
Reporting side effects
Sample Results Reported
32lbs 13-18 lbs 15 pounds 35 lbs (149 lbs down to 114 lbs)
Common Goals
- → Weight loss (achieved 32lbs)
- → Avoid weight loss (maintenance goal), Regain appetite (to reach 140 lbs), Longevity, Improve brain/gut health (e.g., increase Akkermansia muciniphila)
- → Weight loss, Management of severe nerve pain due to tumors, Researching peptides for degenerate condition (braf/RAS and MTOR mutation)
Most Discussed Peptides
Ranked by how frequently they are mentioned in discussions about significant weight loss.
1
325 mentions Tirzepatide Weight Loss
GLP-1/GIP dual receptor agonist
2
204 mentions Retatrutide Weight Loss
GLP-1/GIP/Glucagon triple receptor agonist
3
100 mentions Semaglutide Weight Loss
GLP-1 receptor agonist
4
42 mentions Cagrilintide Weight Loss
Long-acting amylin receptor agonist
5
24 mentions Ipamorelin GH/GHRH
Growth hormone releasing peptide (GHRP)
6
20 mentions Tesamorelin GH/GHRH
Growth hormone-releasing hormone (GHRH) analog
Dosing Patterns for This Goal
Common dosing regimens mentioned by users pursuing significant weight loss. This is not medical advice.
Tirzepatide
5mg weekly 19 mentions
10mg weekly 19 mentions
2.5mg weekly 15 mentions
Retatrutide
1mg weekly 11 mentions
4mg weekly 9 mentions
2mg weekly 9 mentions
Semaglutide
0.25mg weekly 3 mentions
2.4mg weekly 3 mentions
Cagrilintide
0.25mg weekly 3 mentions
250mcg weekly 1 mentions
Ipamorelin
300mcg 2x/day 1 mentions
Popular Stacks
Peptide combinations commonly discussed together for this use case.
110 mentions
69 mentions
45 mentions
33 mentions
27 mentions