Tesamorelin

Also known as: Egrifta

GH/GHRH FDA Approved

Growth hormone-releasing hormone (GHRH) analog

Mechanism of Action

Stimulates pituitary release of growth hormone, reducing visceral adipose tissue.

365
Community Posts
148
Users Discussing
28
Research Articles

Reported Outcomes

Clinical Strength: C (19 trials)

Based on community reports (365 posts). Grade reflects frequency and consistency of positive mentions.

D Body Composition
68 mentions

Changes in muscle vs fat ratio

D Weight Loss
35 mentions

Reduction in body weight

D Sleep Quality
43 mentions

Effects on sleep quality

D Appetite Suppression
22 mentions

Reduced hunger and food cravings

D Energy Levels
17 mentions

Changes in energy and fatigue levels

D Mental/Mood
19 mentions

Effects on mood and cognitive function

D Blood Sugar Control
15 mentions

Improved glycemic control and insulin sensitivity

D Cardiovascular
15 mentions

Effects on heart health markers

Side Effects

Based on 71 user reports. Frequency indicates how often each was mentioned.

Common (>5%)

Fatigue
Mild 14 reports 14.9%
Water Retention
Mild 10 reports 10.6%
Insomnia
Mild 8 reports 8.5%
Nausea
Mild 7 reports 7.4%
Constipation
Mild 7 reports 7.4%
Stinging
Mild 5 reports 5.3%

Uncommon (1-5%)

Hair Loss
Mild 4 reports 4.3%
Pain
Mild 3 reports 3.2%
Food Noise
Mild 3 reports 3.2%
Edema
Mild 2 reports 2.1%
Injection Site Burn
Mild 2 reports 2.1%
Redness
Mild 2 reports 2.1%
Injection Site Reaction (Isr)
Mild 2 reports 2.1%
Anhedonia
Mild 2 reports 2.1%
Lethargy
Mild 2 reports 2.1%
Skin Sensitivity
Mild 2 reports 2.1%
Tiredness
Mild 2 reports 2.1%
Acid Reflux
Mild 2 reports 2.1%
Injection Site Stinging
Mild 2 reports 2.1%
Burning
Mild 2 reports 2.1%

Risks & Warnings

Important safety considerations based on clinical data and community reports.

!

Muscle Loss

6 mentions

Rapid weight loss may include muscle. Adequate protein intake and resistance training recommended.

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Injection Site Reactions

9 mentions

Local reactions are common and usually mild. Rotate injection sites.

i

Gastrointestinal Issues

3 mentions

GI side effects are the most commonly reported. Usually improve over time with slow titration.

Dosing

Standard Protocol

Starting Dose
2mg daily
Titration
Fixed dose
Half-life
26-38 minutes
Administration
Subcutaneous injection, once daily

Community Dosing Patterns

Based on 97 mentions

Community-reported patterns, not medical advice.

1mg daily
11
2mg daily
7
2mg 5x/week
3
daily
2
1.5mg daily
2

Pricing

Research-grade reference pricing for 10mg vial. Prices vary by vendor and quantity.

We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.

US Research Grade

$70

Single small vial from US domestic vendors

US Research Grade (Bulk)

$57

Per-dose equivalent when buying larger US vials

China Research Grade

$17.85

Per-vial when buying 10-pack from Chinese vendors

74% savings

Research

28
Total Articles
19
Clinical Trials
5
Reviews

Key Studies

Dietary regimens appear to possess significant effects on the development of combined antiretroviral therapy (cART)-associated metabolic syndrome Preclinical

PLoS One (2024)

Probing for peptidic drugs (2-10 kDa) in doping control blood samples Preclinical

Anal Sci Adv (2022)

CROI 2024: Neuropsychiatric Complications in People With HIV Review

Top Antivir Med (2024)

Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors Clinical Trial

AIDS (London, England) (2024)

Carpal Tunnel Syndrome Attributed to Medication Use: A Pharmacovigilance Study Other

Cureus (2025)

Commonly Stacked With

Based on 365 community posts mentioning Tesamorelin.

Ipamorelin 93 mentions (25.5%)
Retatrutide 47 mentions (12.9%)
Tirzepatide 34 mentions (9.3%)
CJC-1295 27 mentions (7.4%)
TB-500 23 mentions (6.3%)

Switching Patterns

Based on 30 discussions about switching to or from Tesamorelin.

→ Switching FROM

Retatrutide 4 mentions

Users who switched to Tesamorelin

← Switching TO

Retatrutide 3 mentions

Users who switched from Tesamorelin

Frequently Asked Questions

What is tesamorelin?

Does tesamorelin help with fat loss?

Does tesamorelin reduce visceral fat?

Does tesamorelin increase growth hormone levels?

Does tesamorelin improve body composition?