TB-500

Also known as: Thymosin Beta-4 fragment

Healing FDA Approved

Synthetic peptide fragment

Mechanism of Action

May promote cell migration, tissue repair, and reduce inflammation. Research is primarily preclinical.

343
Community Posts
142
Users Discussing
64
Research Articles

Reported Outcomes

Clinical Strength: C (12 trials)

Based on community reports (343 posts). Grade reflects frequency and consistency of positive mentions.

D Sleep Quality
45 mentions

Effects on sleep quality

D Weight Loss
22 mentions

Reduction in body weight

D Energy Levels
19 mentions

Changes in energy and fatigue levels

D Body Composition
20 mentions

Changes in muscle vs fat ratio

D Mental/Mood
18 mentions

Effects on mood and cognitive function

D Blood Sugar Control
10 mentions

Improved glycemic control and insulin sensitivity

D GI Health
7 mentions

Gastrointestinal effects

D Appetite Suppression
6 mentions

Reduced hunger and food cravings

D Cardiovascular
5 mentions

Effects on heart health markers

Side Effects

Based on 62 user reports. Frequency indicates how often each was mentioned.

Common (>5%)

Fatigue
Mild 18 reports 23.7%
Stinging
Mild 7 reports 9.2%
Nausea
Mild 6 reports 7.9%
Injection Site Reaction (Isr)
Mild 5 reports 6.6%
Hair Loss
Mild 5 reports 6.6%
Tiredness
Mild 5 reports 6.6%
Constipation
Mild 5 reports 6.6%
Insomnia
Mild 5 reports 6.6%
Headache
Mild 4 reports 5.3%

Uncommon (1-5%)

Swelling
Mild 3 reports 3.9%
Dizziness
Mild 3 reports 3.9%
Tolerance
Mild 2 reports 2.6%
Irritability
Mild 2 reports 2.6%
Increased Hunger
Mild 2 reports 2.6%
Stinging Upon Injection
Mild 2 reports 2.6%
Allodynia (Skin Sensitivity)
Mild 2 reports 2.6%
Appetite Suppression
Mild 2 reports 2.6%
Bumps
Mild 2 reports 2.6%
Burning
Mild 2 reports 2.6%
Anhedonia
Mild 2 reports 2.6%

Risks & Warnings

Important safety considerations based on clinical data and community reports.

!

Thyroid Concerns

3 mentions

GLP-1 agonists carry a boxed warning for thyroid C-cell tumors in rodents. Contraindicated in MEN2 or personal/family history of MTC.

!

Hair Loss

5 mentions

May occur with rapid weight loss. Usually temporary (telogen effluvium). Ensure adequate nutrition.

!

Hypoglycemia Risk

3 mentions

Risk increases when combined with insulin or sulfonylureas. Monitor blood sugar carefully.

!

Psychiatric Effects

3 mentions

Monitor for mood changes. Report any concerning psychiatric symptoms to healthcare provider.

i

Injection Site Reactions

12 mentions

Local reactions are common and usually mild. Rotate injection sites.

i

Gastrointestinal Issues

6 mentions

GI side effects are the most commonly reported. Usually improve over time with slow titration.

Dosing

Standard Protocol

Starting Dose
2-2.5mg twice weekly (loading), then weekly
Titration
No established protocol
Half-life
Unknown in humans
Administration
Subcutaneous or intramuscular injection

Community Dosing Patterns

Based on 60 mentions

Community-reported patterns, not medical advice.

1mg daily
3
daily
3
10 units daily
3
1mg 2x/week
2
10 units 5x/week
1

Pricing

Research-grade reference pricing for 10mg vial. Prices vary by vendor and quantity.

We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.

US Research Grade

$70

Single small vial from US domestic vendors

US Research Grade (Bulk)

$60

Per-dose equivalent when buying larger US vials

China Research Grade

$12

Per-vial when buying 10-pack from Chinese vendors

83% savings

Research

64
Total Articles
12
Clinical Trials
4
Reviews

Key Studies

Thymosin Beta 4 Protects Hippocampal Neuronal Cells against PrP (106-126) via Neurotrophic Factor Signaling Preclinical

Molecules (2023)

Proteins from toad's parotoid macroglands: do they play a role in gland functioning and chemical defence? Preclinical

Front Zool (2023)

Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model Preclinical

Cells (2023)

Thymosin beta 4: A potential novel adjunct treatment for bacterial keratitis Other

Int Immunopharmacol (2023)

A Novel Combination Therapy Tβ4/VIP Protects against Hyperglycemia-Induced Changes in Human Corneal Epithelial Cells Preclinical

Biosensors (Basel) (2023)

Commonly Stacked With

Based on 343 community posts mentioning TB-500.

BPC-157 223 mentions (65%)
GHK-Cu 144 mentions (42%)
Retatrutide 57 mentions (16.6%)
Tirzepatide 31 mentions (9%)
MOTS-c 30 mentions (8.7%)

Switching Patterns

Based on 25 discussions about switching to or from TB-500.

Frequently Asked Questions

What is TB-500?

Does TB-500 help with tissue repair?

Does TB-500 reduce inflammation?

Does TB-500 help with muscle injuries?

Can BPC-157 and TB-500 be combined?