MOTS-c

Longevity FDA Approved

Mitochondrial-derived peptide

Mechanism of Action

May improve metabolic function, insulin sensitivity, and exercise capacity. Research is emerging.

607
Community Posts
180
Users Discussing
84
Research Articles

Reported Outcomes

Clinical Strength: C (7 trials)

Based on community reports (607 posts). Grade reflects frequency and consistency of positive mentions.

C Energy Levels
143 mentions

Changes in energy and fatigue levels

C Sleep Quality
70 mentions

Effects on sleep quality

D Weight Loss
60 mentions

Reduction in body weight

D Mental/Mood
36 mentions

Effects on mood and cognitive function

D Appetite Suppression
26 mentions

Reduced hunger and food cravings

D Body Composition
17 mentions

Changes in muscle vs fat ratio

D Blood Sugar Control
10 mentions

Improved glycemic control and insulin sensitivity

D Cardiovascular
8 mentions

Effects on heart health markers

D GI Health
5 mentions

Gastrointestinal effects

Side Effects

Based on 73 user reports. Frequency indicates how often each was mentioned.

Common (>5%)

Fatigue
Mild 20 reports 23.3%
Constipation
Mild 8 reports 9.3%
Injection Site Reaction (Isr)
Mild 8 reports 9.3%
Nausea
Mild 7 reports 8.1%
Water Retention
Mild 6 reports 7.0%
Injection Site Pain
Mild 5 reports 5.8%
Insomnia
Mild 5 reports 5.8%

Uncommon (1-5%)

Acid Reflux
Mild 4 reports 4.7%
Injection Site Reaction
Mild 3 reports 3.5%
Burning
Mild 3 reports 3.5%
Diarrhea
Mild 3 reports 3.5%
Sulfur Burps
Mild 3 reports 3.5%
Allodynia (Skin Sensitivity)
Mild 3 reports 3.5%
Tiredness
Mild 2 reports 2.3%
Food Noise
Mild 2 reports 2.3%
Headaches
Mild 2 reports 2.3%
Dizziness
Mild 2 reports 2.3%
Injection Site Reactions (Isrs)
Mild 2 reports 2.3%
Heartburn
Mild 2 reports 2.3%
Indigestion
Mild 2 reports 2.3%

Risks & Warnings

Important safety considerations based on clinical data and community reports.

!

Thyroid Concerns

3 mentions

GLP-1 agonists carry a boxed warning for thyroid C-cell tumors in rodents. Contraindicated in MEN2 or personal/family history of MTC.

!

Hypoglycemia Risk

3 mentions

Risk increases when combined with insulin or sulfonylureas. Monitor blood sugar carefully.

!

Psychiatric Effects

3 mentions

Monitor for mood changes. Report any concerning psychiatric symptoms to healthcare provider.

i

Injection Site Reactions

93 mentions

Local reactions are common and usually mild. Rotate injection sites.

i

Gastrointestinal Issues

15 mentions

GI side effects are the most commonly reported. Usually improve over time with slow titration.

Dosing

Standard Protocol

Starting Dose
5-10mg weekly
Titration
No established protocol
Half-life
Unknown in humans
Administration
Subcutaneous injection

Community Dosing Patterns

Based on 94 mentions

Community-reported patterns, not medical advice.

5mg 3x/week
11
5mg weekly
3
10mg weekly
3
2.5mg 3x/week
2
10mg EOD
2

Pricing

Research-grade reference pricing for 10mg vial. Prices vary by vendor and quantity.

We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.

US Research Grade

$46.75

Single small vial from US domestic vendors

US Research Grade (Bulk)

$36.13

Per-dose equivalent when buying larger US vials

China Research Grade

$4.5

Per-vial when buying 10-pack from Chinese vendors

90% savings

Research

84
Total Articles
7
Clinical Trials
15
Reviews

Key Studies

Circulating levels of MOTS-c in patients with breast cancer treated with metformin Clinical Trial

Aging (Albany NY) (2022)

The specific mitochondrial unfolded protein response in fast- and slow-twitch muscles of high-fat diet-induced insulin-resistant rats Preclinical

Front Endocrinol (Lausanne) (2023)

Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes Preclinical

Cell Rep (2021)

Prediction of Post-Acute-Sequelae of COVID-19 by Cargo Protein Biomarkers of Blood Total Extracellular Vesicles in Acute COVID-19 Other

Am J Med (2023)

Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function Clinical Trial

Diabetes Metab Syndr Obes (2023)

Commonly Stacked With

Based on 607 community posts mentioning MOTS-c.

Retatrutide 113 mentions (18.6%)
GHK-Cu 34 mentions (5.6%)
Cagrilintide 32 mentions (5.3%)
BPC-157 31 mentions (5.1%)
TB-500 30 mentions (4.9%)

Switching Patterns

Based on 47 discussions about switching to or from MOTS-c.

← Switching TO

Retatrutide 4 mentions

Users who switched from MOTS-c

Frequently Asked Questions

What is MOTS-c?

Does MOTS-c improve insulin sensitivity?

Does MOTS-c improve exercise performance?

Does MOTS-c have anti-aging effects?

What are the side effects of MOTS-c?