BPC-157

Also known as: Body Protection Compound 157

Healing FDA Approved

Synthetic peptide derived from gastric juice protein

Mechanism of Action

May promote angiogenesis, tissue healing, and modulate nitric oxide pathways. Research is primarily preclinical.

377
Community Posts
178
Users Discussing
56
Research Articles

Reported Outcomes

Clinical Strength: C (14 trials)

Based on community reports (377 posts). Grade reflects frequency and consistency of positive mentions.

D Sleep Quality
47 mentions

Effects on sleep quality

D Weight Loss
22 mentions

Reduction in body weight

D Body Composition
19 mentions

Changes in muscle vs fat ratio

D Mental/Mood
20 mentions

Effects on mood and cognitive function

D Energy Levels
16 mentions

Changes in energy and fatigue levels

D GI Health
15 mentions

Gastrointestinal effects

D Blood Sugar Control
8 mentions

Improved glycemic control and insulin sensitivity

D Appetite Suppression
6 mentions

Reduced hunger and food cravings

D Cardiovascular
6 mentions

Effects on heart health markers

Side Effects

Based on 88 user reports. Frequency indicates how often each was mentioned.

Common (>5%)

Fatigue
Mild 19 reports 16.8%
Hair Loss
Mild 8 reports 7.1%
Nausea
Mild 8 reports 7.1%
Injection Site Reaction (Isr)
Mild 7 reports 6.2%
Stinging
Mild 7 reports 6.2%
Constipation
Mild 7 reports 6.2%
Tiredness
Mild 6 reports 5.3%

Uncommon (1-5%)

Insomnia
Mild 5 reports 4.4%
Headache
Mild 4 reports 3.5%
Loose Skin
Mild 3 reports 2.7%
Swelling
Mild 3 reports 2.7%
Exhaustion
Mild 3 reports 2.7%
Injection Site Pain
Mild 3 reports 2.7%
Sulfur Burps
Mild 3 reports 2.7%
Gas
Mild 3 reports 2.7%
Chills
Mild 3 reports 2.7%
Water Retention
Mild 3 reports 2.7%
Dizziness
Mild 3 reports 2.7%
Tolerance
Mild 2 reports 1.8%
Sting
Mild 2 reports 1.8%

Risks & Warnings

Important safety considerations based on clinical data and community reports.

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Thyroid Concerns

5 mentions

GLP-1 agonists carry a boxed warning for thyroid C-cell tumors in rodents. Contraindicated in MEN2 or personal/family history of MTC.

!

Hair Loss

10 mentions

May occur with rapid weight loss. Usually temporary (telogen effluvium). Ensure adequate nutrition.

!

Psychiatric Effects

6 mentions

Monitor for mood changes. Report any concerning psychiatric symptoms to healthcare provider.

!

Hypoglycemia Risk

3 mentions

Risk increases when combined with insulin or sulfonylureas. Monitor blood sugar carefully.

i

Injection Site Reactions

12 mentions

Local reactions are common and usually mild. Rotate injection sites.

i

Gastrointestinal Issues

7 mentions

GI side effects are the most commonly reported. Usually improve over time with slow titration.

Dosing

Standard Protocol

Starting Dose
250-500mcg daily
Titration
No established protocol
Half-life
Unknown in humans
Administration
Subcutaneous injection or oral

Community Dosing Patterns

Based on 109 mentions

Community-reported patterns, not medical advice.

daily
4
10 units daily
3
5x/week
2
1mg daily
2
500mcg daily
2

Pricing

Research-grade reference pricing for 10mg vial. Prices vary by vendor and quantity.

We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.

US Research Grade

$65

Single small vial from US domestic vendors

US Research Grade (Bulk)

$50.9

Per-dose equivalent when buying larger US vials

China Research Grade

$6.8

Per-vial when buying 10-pack from Chinese vendors

90% savings

Research

56
Total Articles
14
Clinical Trials
17
Reviews

Key Studies

Stable Gastric Pentadecapeptide BPC 157 May Recover Brain-Gut Axis and Gut-Brain Axis Function Review

Pharmaceuticals (Basel) (2023)

Antiarrhythmic Sotalol, Occlusion/Occlusion-like Syndrome in Rats, and Stable Gastric Pentadecapeptide BPC 157 Therapy Preclinical

Pharmaceuticals (Basel) (2023)

Stable Gastric Pentadecapeptide BPC 157-Possible Novel Therapy of Glaucoma and Other Ocular Conditions Preclinical

Pharmaceuticals (Basel) (2023)

Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect Preclinical

World J Gastroenterol (2023)

Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats Preclinical

Pharmaceuticals (Basel) (2023)

Commonly Stacked With

Based on 377 community posts mentioning BPC-157.

TB-500 223 mentions (59.2%)
GHK-Cu 149 mentions (39.5%)
Retatrutide 60 mentions (15.9%)
Tirzepatide 36 mentions (9.5%)
MOTS-c 31 mentions (8.2%)

Switching Patterns

Based on 23 discussions about switching to or from BPC-157.

Frequently Asked Questions

What is BPC-157?

Does BPC-157 help with tendon healing?

Does BPC-157 help with gut health?

Does BPC-157 help with muscle injuries?

Can BPC-157 and TB-500 be combined?