Longevity & Metabolic
Metabolic and longevity-focused compounds compared.
| MOTS-c | NAD+ NAD+, Nicotinamide adenine dinucleotide | |
|---|---|---|
| Basic Information | ||
| Status | Research compound (not FDA approved) | Supplement / research compound |
| Class | Mitochondrial-derived peptide | Coenzyme / metabolic cofactor |
| Mechanism | May improve metabolic function, insulin sensitivity, and exercise capacity. Research is emerging. | Essential coenzyme in cellular metabolism. Supplementation aims to restore declining NAD+ levels ass... |
| Dosing | ||
| Starting Dose | 5-10mg weekly | 100-500mg IV or 250-1000mg oral precursors |
| Half-life | Unknown in humans | Variable by form |
| Administration | Subcutaneous injection | IV infusion, subcutaneous, or oral precursors (NMN, NR) |
| Reported Outcomes (Grade) | ||
| Energy Levels | C 143 | — |
| Sleep Quality | C 70 | — |
| Weight Loss | D 60 | — |
| Mental/Mood | D 36 | — |
| Appetite Suppression | D 26 | — |
| Body Composition | D 17 | — |
| Blood Sugar Control | D 10 | — |
| Cardiovascular | D 8 | — |
| Common Side Effects | ||
| Fatigue | 23.3% | — |
| Constipation | 9.3% | 40.0% |
| Injection Site Reaction (Isr) | 9.3% | — |
| Pricing | ||
| US Research Grade | $46.75 | $85 |
| China Research Grade | $4.5 | $9.25 |
| Research & Community | ||
| Research Articles | 84 | 9 |
| Community Posts | 607 | 35 |