NAD+

Also known as: NAD+, Nicotinamide adenine dinucleotide, NAD plus

Longevity Research Compound

Coenzyme / metabolic cofactor

Mechanism of Action

Essential coenzyme in cellular metabolism. Supplementation aims to restore declining NAD+ levels associated with aging.

Note: Precursors (NMN, NR) available as supplements

NAD+ (nicotinamide adenine dinucleotide) generates intense interest as a longevity compound, yet robust evidence remains thin — only 280 unique individuals contribute observational data, and just 1 clinical trial has been identified. Sentiment skews cautiously optimistic: 53 positive versus 11 negative self-reported assessments, though the majority (114) remain neutral — suggesting most individuals are still evaluating outcomes rather than reporting clear benefits.

Community Posts

Users Discussing

Research Articles

Clinical Trials

Reported Outcomes

Clinical grade reflects published research; Community grade reflects user reports (n=35).

Outcome

Clinical

Community

Reported by

Metabolic Health

Metabolic and cellular health improvements

Clinical: C

Community: A

22% (5)

In a model of obesity-induced chronic kidney injury, renal NAD+ levels were found to be depleted; treatment with a GLP-1 receptor agonist restored renal metabolism homeostasis, including NAD+ levels.

Side Effects

Limited data

Based on 2 user reports (n=2). Frequency indicates how often each was mentioned.

Uncommon (1-5%)

Nicotinamide Adenine Dinucleotide Crystalizing

Mild 1 reports 50.0%

Degradation (In Vial)

Mild 1 reports 50.0%

Stinging Twinges At Injection Site

Mild 1 reports 50.0%

Odor (Product Smell)

Mild 1 reports 50.0%

Dosing

Standard Protocol

Starting Dose: 100-500mg IV or 250-1000mg oral precursors
Titration: Varies by form (IV, sublingual, oral precursors)
Half-life: Variable by form
Administration: IV infusion, subcutaneous, or oral precursors (NMN, NR)

Community Dosing Patterns

Based on 98 mentions

Community-reported patterns, not medical advice.

50mg 2x/week

100mg 3x/week

100mg 2x/week

50mg 3x/week

100mg daily

Pricing

Research-grade reference pricing for 500mg vial. Prices vary by vendor and quantity. Research chemicals require self-mixing and lack medical oversight. Shipping is not included.

We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.