NAD+

Also known as: NAD+, Nicotinamide adenine dinucleotide, NAD plus

Longevity Research

Coenzyme / metabolic cofactor

Mechanism of Action

Essential coenzyme in cellular metabolism. Supplementation aims to restore declining NAD+ levels associated with aging.

35
Community Posts
18
Users Discussing
9
Research Articles

Side Effects

Based on 5 user reports. Frequency indicates how often each was mentioned.

Common (>5%)

Constipation
Mild 2 reports 40.0%

Dosing

Standard Protocol

Starting Dose
100-500mg IV or 250-1000mg oral precursors
Titration
Varies by form (IV, sublingual, oral precursors)
Half-life
Variable by form
Administration
IV infusion, subcutaneous, or oral precursors (NMN, NR)

Community Dosing Patterns

Based on 98 mentions

Community-reported patterns, not medical advice.

50mg 2x/week
4
100mg 3x/week
4
100mg 2x/week
2
50mg 3x/week
2
100mg daily
2

Pricing

Research-grade reference pricing for 500mg vial. Prices vary by vendor and quantity.

We do not list vendors. Prices are aggregated from community reports and should be treated as rough ranges.

US Research Grade

$85

Single small vial from US domestic vendors

US Research Grade (Bulk)

$73.33

Per-dose equivalent when buying larger US vials

China Research Grade

$9.25

Per-vial when buying 10-pack from Chinese vendors

89% savings

Research

9
Total Articles
1
Clinical Trials
0

Key Studies

Cascade-catalysed nanocarrier degradation for regulating metabolism homeostasis and enhancing drug penetration on breast cancer Preclinical

J Nanobiotechnology (2024)

Provoking tumor disulfidptosis by single-atom nanozyme via regulating cellular energy supply and reducing power Preclinical

Nat Commun (2025)

High-Efficiency Carriers' Separation Strategy Based Ultrasmall-Bandgap CuWO(4) Sono-Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy Preclinical

Adv Sci (Weinh) (2025)

GLP-1 receptor agonist ameliorates obesity-induced chronic kidney injury via restoring renal metabolism homeostasis Preclinical

PLoS One (2018)

Liraglutide reduces hepatic glucolipotoxicity‑induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats Preclinical

Mol Med Rep (2018)

Frequently Asked Questions

What is NAD+?

Does NAD+ improve metabolic function?

Does NAD+ help with energy levels?

Does NAD+ slow aging?

Does NAD+ improve cognitive function?