GLP-1s & Next-Gen Agonists
Semaglutide vs tirzepatide vs retatrutide (and related agents).
Semaglutide
FDA Approved Ozempic, Wegovy
GLP-1 receptor agonist
Starting Dose
0.25mg weekly
Half-life
~7 days
US Price
$75
Research Articles
1,345
Top Outcomes (Clinical / Community)
Weight Loss: A / B
Blood Sugar Control: A / B
Sleep Quality: C / B
Appetite Suppression: A / B
Tirzepatide
FDA Approved Mounjaro, Zepbound
GLP-1/GIP dual receptor agonist
Starting Dose
2.5mg weekly
Half-life
~5 days
US Price
$100
Research Articles
477
Top Outcomes (Clinical / Community)
Weight Loss: A / B
Sleep Quality: A / B
Appetite Suppression: A / B
Blood Sugar Control: A / B
Retatrutide
Phase 3 Trials LY3437943
GLP-1/GIP/Glucagon triple receptor agonist
Starting Dose
1-2mg weekly (research protocols)
Half-life
~6 days (estimated)
US Price
$100
Research Articles
32
Top Outcomes (Clinical / Community)
Weight Loss: A / B
Appetite Suppression: A / B
Sleep Quality: C / B
Energy Levels: D / B
Phase 3 Trials
Long-acting amylin receptor agonist
Starting Dose
0.3mg weekly (research protocols)
Half-life
~7 days
US Price
$80
Research Articles
11
Top Outcomes (Clinical / Community)
Appetite Suppression: B / B
Weight Loss: A / B
Sleep Quality: D / B
Energy Levels: C / B
| Semaglutide Ozempic, Wegovy | Tirzepatide Mounjaro, Zepbound | Retatrutide LY3437943 | Cagrilintide | |
|---|---|---|---|---|
| Basic Info | ||||
| Status | FDA Approved | FDA Approved | Phase 3 Trials | Phase 3 Trials |
| Class | GLP-1 receptor agonist | GLP-1/GIP dual receptor agonist | GLP-1/GIP/Glucagon triple receptor agonist | Long-acting amylin receptor agonist |
| Dosing | ||||
| Starting Dose | 0.25mg weekly | 2.5mg weekly | 1-2mg weekly (research protocols) | 0.3mg weekly (research protocols) |
| Half-life | ~7 days | ~5 days | ~6 days (estimated) | ~7 days |
| Outcomes (Clinical / Community) | ||||
| Weight Loss | A / B | A / B | A / B | A / B |
| Blood Sugar Control | A / B | A / B | A / B | C / B |
| Sleep Quality | C / B | A / B | C / B | D / B |
| Appetite Suppression | A / B | A / B | A / B | B / B |
| Mental/Mood | C / B | B / B | C / B | D / B |
| Body Composition | B / B | B / B | B / B | D / A |
| Common Side Effects | ||||
| Nausea | 14% | 7% | 8% | 13% |
| Constipation | 12% | 9% | 10% | 16% |
| Fatigue | 12% | 10% | 12% | 21% |
| Pricing & Data | ||||
| US Research | $75 | $100 | $100 | $80 |
| China Research | $3.67 | $2.85 | $5.88 | $8.5 |
| Research Articles | 1,345 | 477 | 32 | 11 |
| Community Posts | 1,248 | 3,333 | 5,896 | 1,824 |